Photo Credit: C. Lüscher
Education and Training
Honours Bachelor of Science (2004-2008)
University of Toronto - Scarborough
Doctor of Philosophy (2008-2012)
University of Toronto - Center for Addiction and Mental Health
Supervisor: Dr. José N. Nobrega
Post-doctoral Fellow (2012-2016)
University of Geneva - Department of Basic Neuroscience
Supervisor: Dr. Christian Lüscher
Meaghan Creed, PhD
I obtained my HBSc ad PhD at the University of Toronto. During my graduate work with Dr. José Nobrega, I studied deep brain stimulation (DBS) applied to the basal ganglia in models of movement disorders. For post-doctoral training, I moved to the lab of Dr. Christian Lüscher at the University of Geneva in Switzerland. Here, I used optogenetics and electrophysiology to understand how cocaine re-wires the brains' reward circuitry, and developed a novel protocol for DBS that reversed cocaine-evoked synaptic plasticity and abolished maladaptive behavior induced by drug exposure.
In order to treat any condition, we must first understand its underlying pathology. To this end, research in the Creed lab applies a variety of approaches to understand how plasticity in the limbic system mediates behaviors such as reward-seeking, risk tolerance, impulsivity and anhedonia. Our ultimate goal is to develop neuromodulatory strategies that would regulate reward circuit function in models of mood- and substance-use disorders, and could be used to normalize behavioral symptoms of these disorders.
Jessica Tooley is from southern Wisconsin and attended St. Norbert College. She graduated with a BA in Psychology before joining the Creed Lab. Jessica has been performing behavioral assays with in vivo electrophysiology recordings in the lab, and plans to go on to graduate school to study neuroscience.
Lauren Marconi was born and raised in Philadelphia, PA and received a BA in Biology from Franklin and Marshall College. Her undergraduate research involved understanding the photosensitive properties and physiology of ion channels in adult sea urchin tube feet by using patch-clamp electrophysiology. Lauren plans to continue patching in the Creed Lab and to apply to graduate school for neuroscience or to a health professions school.